Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA
and protein, and CREB mRNA in cultured hippocampal neurons.
細胞內鋅的消耗下調培養的海馬神經元中CREB mRNA的表達
Magnesium is required for specific DNA binding of the CREB B-ZIP domain.
對於CREB B-ZIP結構域的特異性DNA結合,需要鎂。
Mg2+ ions enhanced the binding affinity of wild-type CREB
鎂離子(Mg2+)增強了野生型CREB的結合親和力
CREB transcriptional activity in neurons is regulated by multiple,
calcium-specific phosphorylation events.
神經元中的CREB轉錄活性受多種鈣特異性磷酸化事件的調節。
The triple phosphorylation of CREB is required for effective Ca(2+) stimulation
of CREB-dependent transcription
CREB的三重磷酸化的CREB依賴性轉錄需要有效鈣離子(Ca2+)刺激
小結2:
到此,看來與長期記憶有關的CREB蛋白質需要鎂鋅鈣來發揮效力。